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What happens in detox

Not knowing what detox is like keeps a lot of people from starting. Here is what a typical stay looks like.

A typical timeline

WhenWhat usually happens
ArrivalIntake, a health check, a drug test, and a talk about your history
First 24 to 72 hoursWithdrawal is often strongest. Staff check you often and give medication for symptoms
Days 3 to 7Symptoms ease. Sleep and appetite start to return. You meet counselors and plan next steps
DischargeA warm handoff to residential, PHP or IOP care

Every substance and every person is different. Your team will explain your plan.

Common withdrawal symptoms

  • Anxiety, restlessness and trouble sleeping
  • Sweating, chills, aches
  • Nausea or upset stomach
  • Cravings
  • For alcohol or benzodiazepines: shaking, and sometimes seizures, which is why medical care matters

Withdrawal by substance

SubstanceTypical timingWhy medical care matters
AlcoholStarts 6 to 24 hours after the last drink, peaks around days 1 to 3Seizures and delirium tremens (DTs) can be life-threatening
BenzodiazepinesCan start days later and last weeksStopping suddenly can cause seizures; doses are tapered slowly
Opioids and fentanylStarts within hours, peaks around days 2 to 3Severe discomfort; starting buprenorphine or methadone helps and lowers overdose risk
Stimulants (meth, cocaine)Days to a couple of weeksExhaustion, low mood and sometimes depression or suicidal thoughts need watching

These are general patterns. Your own timeline depends on how much and how long you used, other substances, and your health.

Medications that may be used

Detox staff may use medications to keep you safe and more comfortable, for example benzodiazepines on a careful schedule for alcohol withdrawal, buprenorphine for opioid withdrawal, and medicines for nausea, sleep or anxiety. Ask the program which medications they use, and whether a doctor or nurse practitioner sees you.

What detox feels like

Most people describe the first days as rough: tired, achy, anxious and restless, with poor sleep. Staff check on you often, sometimes every few hours. By the end of the first week, many people feel clearer and start thinking about what comes next. It helps to know that the hardest part is usually short.

Families can usually call to check that you arrived safely, but staff need your written permission to share details about your care.

Questions to ask a detox program

  • Is a doctor or nurse on site or on call 24/7?
  • Which medications do you use for withdrawal?
  • What happens if I have a medical emergency?
  • Can you start medication for opioid or alcohol use disorder before I leave?
  • Will you help arrange my next level of care?

Before you call a program

  • Ask for the DHCS license or certification number and check it.
  • Ask which levels of care they provide on site.
  • Ask what your insurance covers and what you will owe.
  • Ask where you would go next when this level of care ends.

More questions to ask →

Frequently asked questions

Is detox painful?

It is often uncomfortable, but medical detox is designed to make withdrawal safer and more bearable with medication and monitoring.

Can I have visitors during detox?

Usually not in the first few days, so you can rest and staff can monitor you. Ask the program about its policy.

Last reviewed November 9, 2026. General information only, not medical advice. In an emergency call 911.

You don’t have to figure this out alone.